BPT BITS

In the production of monoclonal antibodies (MCA), the cells of hybridoma clone immobilized in a hollow fiber reactor using ------------------------ gel.[ c ]
a. Agar b. A Cacia c. Polyacryl amide d. Polyamide


The rejection of transplanted organs, especially kidney transplants, is associated with OKT-3 antigen present on the surface of ----------------- cells.[ a ]
a. T-cell b. B-Cells c. Nerve cell d. Lymphocytes


Tumour Necrosis factor (TNF) is a protein that ------------ [ b ]
a. Fasten the growth and kills the cancer cells
b. Shows down the growth and kills the cancer cells
c. Stop the growth and kills the cancer cells.
d. None


Antibodies Consisting of parts of polypeptide chains of two different species are called
[ a ]
a. Chimeric antibodies b. Monoclonal antibodies c. Hybridoma d. Clone


The antigen binding site consists of ------------------ polypeptide chains. [ b ]
a. One b. Two c. Three d. Four


Insulin, a hormone secreted by ----------------- cells of the Islets of Laugerhans of Pancrease.
a. Alpha b. Beta c. Garua d. Delta


Inadequate secretions of Insulin leads to ----------------- [ c ]
a. Increased B.P b. Hypoglyceucia c. Hyperglycemia d. Hypoglycosurea


To cleave the b-galactosidase from the Insulin polyptide ---------------- is used [ c ]
a. Cyauogen Chloride b. Cynogen fluoride c. Cyanogen Bromide
d. None


Somatoltropin is a protein acorns hormone since it consists of CooH group at one end and --------------------- at other end of its structure. [ b ]
a. Nitrogroup b. Ammonia Group c. Sulphide group
d. Phenolic group


a - Interferons are produced by virus infected --------------------- [ a ]
a. Leucocytes b. Lymphocytes c. Erythrocytes d. Thrombocytes


b - Interferone are produced by virus infected --------------------- [ c ]
a. Leucocytes b. Erythrocytes c. Fibroblasts d. Monocytes


The --------------- interferons are also known as leucocytic interferons [ a ]
a. a b. b c. g d. l


The purified interferons after production are dried by -------------- method [ c ]
a. Dry heat b. Moist heat c. Freezing d. Chemical


Interleukins are small glycoproteins that stimulate the proliferation of ----------- cells [ a ]
a. B-cells b. Erythrocytes c. Leucocytes d. Thrombocytes


Interleukin – 2 (IL-2) is used to treat -------------------- [ c ]
a. Tuberculosis b. Control HIV c. Malignant melanoma d. Viral fever

Compounds that dissolve blood clots in the blood vessels and cavity of the heart are called. [c]
a. Thrombocytes b. Clotting agents c. Haemolytics d. Thrombolytics


The small protein that stimulates the bone marrow to produce more red blood cells is [ a ]
a. Erythropoietin b. Erythromycin c. Haemopoietin d. All the above


Suspension of killed or modified live virus or bacterium injected into the body to stimulate immunity against the pathogen is called ---------------- [ d ]
a. Antibiotic b. Antiviral c. Antibacterial d. Vaccine


Testing of newborn children for genetic disease, is known as ---------------- [ c ]
a. Parental Screening b. Antenatal Screening c. Postnatal Screening
d. Gene therapy


Diagnosis of genetic disorders in fetus while it is in mother’s womb is called as [ b ]
a. Parental Screening b. Antenatal Screening c. Postnatal Screening
d. Gene therapy


The protein which catalyse the biochemical reactions in living cells is [ b ]
a. Harmone b. Enzyme c. Vitamin d. Metabolite


Which of the following method adopted for culturing microorganisms to produce enzymes
a. Solid substrate cultivation b. Deep bed cultivation
c. Submerged cultivation d. All the above


Which of the following is an antibacterial drug. [ c ]
a. Penicillin b. Streptomycin c. Ciprofloxacin d. None


Protein component of an enzyme is known as --------------- [ d ]
a. Holoenzyme b. Co-enzyme c. Endoenzyme d. Apoenzyme


Which of the following is NOT an Exoenzyme [ d ]
a. Amylase b. Lipase c. Protease d. Lipase


In prokaryotic cells the DNA present in [ b ]
a. Nuclei b. Protoplasm c. Chloroplast d. Mitochondria


In prokaryotic cells the DNA occurs freely in the for of [ c ]
a. Nucleic acid b. Ribosome c. Nucleoid d. Nuclein


Nucleic acids containing ribose sugar as pentose sugar are known as -------------- [ a ]
a. RNA b. DNA c. Ribosome d. Nucleotide


RNA contains Uracil instead of ---------------- as nitrogen base. [ c ]
a. Adenine b. Guanine c. Thymine d. Cytosine


Transfer RNA is known as soluble RNA since it is soluble in --------------- [ c ]
a. Water b. Fat c. Nacl d. Acid


Which one of the following is a Biopharmaceutical compound [ b ]
a) Glucose b) Insulin c) Glycerol d) Fatty acid


Which one of the following is not a Biopharmaceutical compound [ d ]
a) Therapeutic proteins b) Antibodies c) Interferons d) Ethonol


Odd man out [ d ]
a) Glycoproteins b) Antibodies c) Enzymes d) Antibiotics


Genetic engineering refers to [ c ]
a) Proteomics b) Genomics c) Recombinant DNA technology
d) Tissue culture


The first antibody released in immune response mechanism is [ b ]
a) Ig M b) Ig G c) Ig E d) Ig A


The production of ? – DNA protein is depends up on [ a ]
a) Plasmids b) Microbes c) Plants d) Animals



Which one of the following is not a therapeutic protein [ d ]
a) Insulin b) Antibodies c) Interferons d) Haemoglobin


Hormones are ………………… by nature [ a ]
a) Steroids b) Low molecular wt. organic compounds c) High density proteins d) Lipids
Antiviral protein substance is [ c ]
a) Cytokines b) IAA c) Interferons d) Steroids


Ribozyme is [ d ]
a) RNA b) mRNA c) tRNA d) RNA with catalytic activity


Cytokines are …………. . by nature . [ c ]
a) RNA molecules b) DNA molecules
c) Protein molecules d) Lipids



Biocatalyst may be. [ d ]
a) Ribozymes b) Enzymes c) Abzymes d) All the above



The material used for preparation of capsule shell [ a ]
a) Gelatin b) Glycolipids c) Starch d) Calcium carbonate



The material used as drug delivery system is [ b ]
a) Proteins b) Liposomes c) Triglycerides d) Fats



Which of the following is a broad spectrum antibiotic [ b ]
a) Penicillin b) Streptomycin c) Paracetamol d) Erythromycin



The production of monoclonal antibodies can be considered as [ c ]
a) Hybrid synthesis b) Hybrid technology c) Hybridoma technology
d) Cancer cell technology



Antibodies can be used in [ d ]
a) Detection of diseased b) Treatment of diseases
c) Construction of Biosensors d) All the above



Tumor is a result of [ a ]
a) Abnormal and uncontrolled cell division
b) Controlled cell division
c) Meosis d) None of the above



Cholera is mainly due to [ a ]
a) Water contamination b) Food contamination
c) Air pollution d) Soil pollution



The sustained delivered drug may be [ b ]
a) Antibodies b) Insulin c) Glycoproteins d) Lipases




Lyposomes are Uni or multilayered vesicles of ---------------------- [ c ]
a. Enzymes b. Harmones c. Phospholipids d. Carbohydrates



In subdermal implants for controlled drug delivery, which of the following is NOT the mechanism of controlled delivery. [ d ]
a. Diffusion b. Swelling c. Osmosis d. Carrier medicated



Which of the following material as implant is used for subdermal controlled drug delivery
a. Carbon b. Metal c. Polymer d. Plastic

[ c ]

Material used for needle injection catheter is [ d ]
a. Carbon b. Graphite c. Copper d. Polyethylene



The compound formed by chemical modifications to enhance the absorption is known as
a. Drug b. Co-Drug c. Prodrug d. Carrier

[ c ]

Multilammelar liposomes have a diameter range of [ c ]
a. 1 nm to 4 µm b. 10 nm to 4 µm c. 25 nm to 4 µm d. 50 nm to 4 µm



One of the following mechanism is NOT applicable to Liposome – cell interaction in drug delivery. [ b ]
a. Endocytosis b. Exocytosis c. Fusion d. Adsorption


Increased protein intake is accompanied by an increased dietary requirement for [ a ]
a. Thiamine b. Riboflavin c. Folic acid d. Nicotinic acid


A pathway that require NADPH as a cofactor is [ a ]
a. Extramitochondrial folic acid synthesis b. Ketone body formation
c. Glycogenesis d. Gluconeogenesis


In mammalian cells, ribosomal RNA is produced mainly in [ b ]
a. Nucleus b. Nucleolus c. Ribosome d. Golgiapparatus


Inactive zymogens are precursors of all the following gastrointestinal enzymes, except…
a. Carboxypeptidase b. Pepsin c. Aminopeptidase d. Chymotrypsin

[ c ]
An antibiotic which has a half-life of one day is formulated as a tablet. How many milligrams of antibiotic would remain after three days? [ a ]
a. 25 b. 50 c. 100 d. 200


Streptokinase may be indicated for the treatment of [ b ]
a. Impaired fat absorption b. Pulmonary Emboli
c. Tuberculosis d. Neoplastic disorders


Lactic acid is --------------- [ c ]
a. Ethandioic acid b. Dihydroxysuccinic acid
c. 2-hydroxypropionic acid d. Ethanoic acid


Man cannot synthesis vitamin [ c ]
a. A b. B c. C d. D


Glycogen is present is all body tissues except. [ b ]
a. Liver b. Brain c. Kidney d. Stomach


Cholesterol, bilesalts, vitamin and sex harmones are [ d ]
a. Mucolipids b. Glycolipids c. Phospholipids d. Isoprenoidlipids


Vitamin – A is required for formation of light receptor protein [ d ]
a. Globulins b. Lipoproteins c. Chromoproteins d. Rhodopsin




Hapten is --------------- [ d ]
a. Partial antigen b. Complete antigen c. High molecular with protein
d. Immunoglobulin


CD4 cells are also known as ------------------ [ a ]
a. T4 cells b. Helper T-cells c. Killer T-cells d. Both a & b


A highly sensitive semi quantitative methods of detecting microbial antigen in biological fluid is done by [ b ]
a. Radio immuno electrophoresis b. Counter immuno electrophoresis
c. H.P.L.C d. Freeze dried centrifugal methods


Infected blood products may produce serum hepatitis due to presence of -------------- [ b ]
a. Hepatitis – A virus b. Hepatitis – B virus
c. Hepatitis – C virus b. All the above


Small pox vaccine contains [ c ]
a. Living virus Vaccine b. Living culture of B.C.G
c. Attenuated staphylococcus d. Living virus of hepatitis


Wasermann test complement fixation is used for the cliagnosis of [ b ]
a. Small pox b. Syphilis c. Typhoid d. Rabbies


Among the immunizing agents listed below one of them is orally administered. [ c ]
a. Tetanus Toxoid b. Rabies Vaccine c. Poliomyelitis Vaccine
d. Mumps virus vaccine


An example of cytokine is [ a ]
a. Interlenkin b. Insulin c. Gonadotropin d. Thyroxin


How many nucleotides are normally present in tRNA of both prokaryotic and Eukaryotic cells? [ c ]
a. 1700 nucleotides b. 3700 nucleotides c. 75 nucleotides d. 120 nucleotides


Vitamin B12 is obtained biotechnology from [ b ]
a. Micrococcus glutamicus b. Propioni Bacterium shermani
c. Eremotheciumm cerevisiae d. None


The gene responsible for onset and development of caner in human are called [ c ]
a. Master gene b. Slave gene c. Oncogene d. control gene


The pH which an enzyme has maximum activity is known as [ b ]
a. Isoelectric pH b. Optimum pH c. Low pH d. High pH